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Product Name
[KO] Cyclin E2 Rabbit mAb
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Gene ID
9134
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SwissProt ID
O96020
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Gene Name
CCNE2
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Alternative Names
CCNE2; G1/S-specific cyclin-E2
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Background
The human Cyclin E2 gene encodes a 404 amino acid protein that is most closely related to Cyclin E. Cyclin E2 mRNA levels peaks at the G1 / S transition. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27 (Kip1) and p21 (Cip1). Cyclin E2 / Cdk2 phosphorylates histone H1 in vitro. G1 cyclin E controls the initiation of DNA synthesis by activating CDK2. Abnormally high levels of cyclin E expression have frequently been observed in human cancers.
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Research Field
Cell Biology
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Product Categories
KO/KD validated
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Host
Rabbit
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Reactivity
Human
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Application
WB,ICC/IF,IP
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
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Molecular Weight
Calculated MW: 47 kDa; Observed MW: 47 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R04-1A4
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Isotype
IgG
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Immunogen
A synthetic peptide of human Cyclin E2
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.