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Product Name
[KD] Nicastrin Rabbit mAb
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Gene ID
23385
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SwissProt ID
Q92542
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Gene Name
NCSTN
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Alternative Names
APH2; Ncstn; NCT; Nicastrin
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Background
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
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Research Field
Neuroscience
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Product Categories
KO/KD validated
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IP
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Dilution Ratio
WB: 1/500-1/1000 IP: 1/20
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Molecular Weight
Calculated MW: 78 kDa; Observed MW: 110-120 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R02-9E6
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Isotype
IgG
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Immunogen
A synthetic peptide of human Nicastrin
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.