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货号： R24197

别名： EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I

应用： WB,IHC-P,IP

反应种属： Human,Mouse,Rat,Hamster

目录价格：

RMB(含税报价)

数量： - + （库存件）

查看代理商预计货期：现货说明书PDF

产品详情

Product Name

[KO] 4E BP1 Rabbit mAb
Gene ID

1978
SwissProt ID

Q13541
Gene Name

EIF4EBP1
Alternative Names

EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
Background

Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.
Research Field

Epigenetics and Nuclear Signaling
Product Categories

KO/KD validated
Host

Rabbit
Reactivity

Human,Mouse,Rat,Hamster
Application

WB,IHC-P,IP
Dilution Ratio

WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
Molecular Weight

Calculated MW: 13 kDa; Observed MW: 15-20 kDa
Clonality

Monoclonal Antibody
Clonality No.

R06-8E6
Isotype

IgG
Immunogen

A synthetic peptide of human eIF4EBP1
Purification

Affinity Purified
Conjugation

Unconjugated
Modification

Unmodified
Form

Liquid
Buffer System

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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验证详情

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应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。

引用文献更多完整详情

标题： Retinoic acid and RARγ maintain satellite cell quiescence through regulation of translation initiation

样本种属： Mouse

杂志： Cell Death & Disease

应用： WB

IF： 9.69

文献链接

标题： Romidepsin exhibits anti-esophageal squamous cell carcinoma activity through the DDIT4-mTORC1 pathway

样本种属： Human

杂志： CANCER GENE THERAPY

应用： WB

IF： 6.4