-
Product Name
[KO] IDH1 Mouse mAb
-
Gene ID
3417
-
SwissProt ID
O75874
-
Gene Name
IDH1
-
Alternative Names
IDH1; PICD; Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; Cytosolic NADP-isocitrate dehydrogenase; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase
-
Background
Genetic variations are associated with cartilaginous tumors such as enchondroma or chondrosarcoma. Mutations of Arg-132 to Cys, Gly or His abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.
-
Research Field
Signal Transduction
-
Product Categories
KO/KD validated
-
Host
Mouse
-
Reactivity
Human,Mouse,Rat
-
Application
WB,IHC-P
-
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100
-
Molecular Weight
Calculated MW: 47 kDa; Observed MW: 47 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
3G9
-
Isotype
IgG1
-
Immunogen
Purified recombinant human IDH1 protein fragments expressed in E.coli.
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.