-
Product Name
[KO] ErbB 2 Mouse mAb
-
Gene ID
2064
-
SwissProt ID
P04626
-
Gene Name
ERBB2
-
Alternative Names
ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340
-
Background
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.
-
Research Field
Cancer
-
Product Categories
KO/KD validated
-
Host
Mouse
-
Reactivity
Human,Mouse,Rat
-
Application
WB,IHC-P
-
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100
-
Molecular Weight
Calculated MW: 138 kDa; Observed MW: 180 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
9G2
-
Isotype
IgG2b
-
Immunogen
Purified recombinant human ERBB2 protein fragments expressed in E.coli.
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.