-
Product Name
[KO] Chk2 Mouse mAb
-
Gene ID
11200
-
SwissProt ID
O96017
-
Gene Name
CHEK2
-
Alternative Names
CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2
-
Background
These are known to be preferred sites for phosphorylation by ATM/ATR kinases. After DNA damage by ionizing radiation (IR), UV irradiation, or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function.
-
Research Field
Epigenetics and Nuclear Signaling
-
Product Categories
KO/KD validated
-
Host
Mouse
-
Reactivity
Human,Mouse,Rat
-
Application
WB,IHC-P,ICC/IF,FC
-
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 ICC: 1/100-1/200 FC: 1/50-1/100
-
Molecular Weight
Calculated MW: 61 kDa; Observed MW: 61 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
5C4
-
Isotype
IgG1
-
Immunogen
Full length human recombinant protein of human CHEK2 produced in 293T cell.
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.