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Product Name
[KO] HIF1 beta Mouse mAb
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Gene ID
405
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SwissProt ID
P27540
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Gene Name
ARNT
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Alternative Names
ARNT; BHLHE2; Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor; nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta
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Background
HIF-1β is also known as AhR nuclear translocator (ARNT) due to its ability to partner with the aryl hydrocarbon receptor (AhR) to form a heterodimeric transcription factor complex. Together with AhR, HIF-1β plays an important role in xenobiotics metabolism. In addition, a chromosomal translocation leading to a TEL-ARNT fusion protein is associated with acute myeloblastic leukemia. Studies also found that ARNT/HIF-1β expression levels decrease significantly in pancreatic islets from patients with type 2 diabetes, suggesting that HIF-1β plays an important role in pancreatic β-cell function.
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Research Field
Cardiovascular
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Product Categories
KO/KD validated
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Host
Mouse
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Reactivity
Human,Mouse,Rat
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Application
WB,ICC/IF,FC
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Dilution Ratio
WB: 1/500-1/1000 ICC: 1/100-1/200 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 87 kDa; Observed MW: 110 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
2C7
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Isotype
IgG1
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Immunogen
Full length human recombinant protein of human ARNT produced in 293T cell.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.