产品详情
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Product Name
[KO] YAP Mouse mAb
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Gene ID
10413
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SwissProt ID
P46937
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Gene Name
YAP1
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Alternative Names
YAP1; YAP65; Yorkie homolog; 65 kDa Yes-associated protein; YAP65
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Background
YAP (Yes-associated protein, YAP65) was identified based on its ability to associate with the SH3 domain of Yes. Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
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Research Field
Signal Transduction
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Product Categories
KO/KD validated
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Host
Mouse
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Reactivity
Human,Mouse
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 54 kDa; Observed MW: 70 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
6B11
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Isotype
IgG1
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Immunogen
Purified recombinant human YAP1 protein fragments expressed in E.coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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