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Product Name
[KO] TAK1 Mouse mAb
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Gene ID
6885
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SwissProt ID
O43318
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Gene Name
MAP3K7
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Alternative Names
MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1
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Background
Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
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Research Field
Signal Transduction
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Product Categories
KO/KD validated
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Host
Mouse
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Reactivity
Human,Rat
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 67 kDa; Observed MW: 80 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
9D2
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Isotype
IgG1
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Immunogen
Purified recombinant human MAP3K7 protein fragments expressed in E.coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.