总的来说,细胞凋亡的调节大致可以分为Caspase依赖的和不依赖的两类。对Caspase的抑制,大多只能延缓细胞凋亡的过程,并不能完全避免凋亡的发生。但是对于凋亡研究来说,Caspase仍然是其核心机制分子。Caspase家族包含多种蛋白,其中Caspase-1和Caspase-4主要负责白介素前体的活化,并不直接参与凋亡信号的传递。被称为凋亡启动蛋白的Caspase-2, -8, -9, -10和-12主要负责对执行者的前体进行切割,从而产生有活性的效应蛋白。Caspase-3, -6和-7则可以直接切割细胞核内或细胞质中的结构蛋白和调节蛋白,以执行凋亡程序。一般来说,PARP和Lamin A/C等靶蛋白可被活化的Caspase剪切,随后成为凋亡的标记,ROCK被切割后则会影响质膜稳定性,促进凋亡的发生。
凋亡相关靶标 | 产品货号 | 精品抗体 | 重组兔单抗 | 产品名称 | 反应种属 | 应用 |
死亡受体相关 | R24283 | √ | √ | Fas Rabbit mAb | Human | WB,IHC-F,IHC-P,ICC/IF |
501540 |
|
| TNF Receptor 1 Rabbit pAb | Human,Mouse,Rat | WB,IHC-P |
200822 | √ |
| TNFRSF10B (7F4) Mouse mAb | Human,Mouse | WB,ICC/IF |
R24275 | √ | √ | FADD Rabbit mAb | Mouse,Rat | WB,IP |
820622 |
|
| FADD Rabbit pAb | Human,Mouse | WB,IHC-P,ELISA |
R25279 | √ | √ | PARP1 Rabbit mAb | Human,Mouse,Rat | WB,IHC-F,IHC-P,ICC/IF |
380374 | √ |
| Cleaved-PARP1 Rabbit pAb | Human | WB,ICC/IF,IP,FC |
R24823 | √ | √ | Lamin A/C Rabbit mAb | Human,Mouse,Rat | WB,IHC-F,IHC-P,ICC/IF,IP |
R24647 | √ | √ | ICAD Rabbit mAb | Human,Rat | WB |
R25607 | √ | √ | ROCK1 Rabbit mAb | Human,Mouse,Rat | WB,IP |
R22622 | √ | √ | ROCK2 Rabbit mAb | Human,Rat | WB,ICC/IF |
caspase凋亡启动子 | 381055 |
|
| Caspase 2 Rabbit pAb | Human,Mouse,Rat | WB,IHC-P,ICC/IF,FC |
250106 | √ |
| Caspase 8 (2G12) Mouse mAb | Human,Mouse,Rat | WB,IHC-F,IHC-P,ICC/IF |
R22844 | √ | √ | Caspase 9 Rabbit mAb | Human,Mouse | WB,IP |
381238 |
|
| Cleaved-Caspase 9 Rabbit pAb | Human,Mouse | WB,IP |
R23723 | √ | √ | Caspase 10 Rabbit mAb | Human | WB,IHC-P,IP |
160136 |
|
| Caspase 12 Rabbit pAb | Human,Mouse | WB,IHC-P,ELISA |
caspase凋亡效应器 | R23315 | √ | √ | Caspase 3 Rabbit mAb | Human,Mouse,Rat | WB,IHC-P,IP |
380169 | √ |
| Cleaved-Caspase 3 p17 Rabbit pAb | Human | WB,IHC-P,ICC/IF |
R26517 | √ | √ | Caspase 6 Rabbit mAb | Human | WB,IHC-P |
341036 |
|
| Cleaved-Caspase 6 p18 Rabbit pAb | Human,Rat | WB,IHC-P,ELISA |
R26518 | √ | √ | Caspase 7 Rabbit mAb | Human,Mouse,Rat | WB,IHC-P |
R27200 | √ | √ | Caspase 7 Rabbit mAb | Human | WB,IHC-P |
caspase其他蛋白 | 381016 | √ |
| Caspase 1 Rabbit pAb | Human,Rat | WB,IHC-P |
341030 | √ |
| Cleaved-Caspase 1 Rabbit pAb | Human | WB,ICC/IF,IHC-F,IHC-P,ELISA |
381294 |
|
| Caspase 5 Rabbit pAb | Human | WB,IHC-P,ICC/IF,IP |
347416 |
|
| Cleaved-Caspase 4/5 p20 Rabbit pAb | Human | WB,ELISA |
R23724 | √ | √ | Caspase 11 Rabbit mAb | Mouse | WB,IP |
线粒体相关 | R22867 | √ | √ | Cytochrome C Rabbit mAb | Human,Mouse,Rat | WB,IHC-P,IP |
380882 |
|
| APAF1 Rabbit pAb | Human,Mouse | WB,IHC-P,ICC/IF |
201149-8H1 | √ |
| AIF (8H1) Mouse mAb | Human | WB,ICC/IF |
382307 |
|
| Endo G Rabbit pAb | Human,Mouse,Rat | WB |
R26117 | √ | √ | XIAP Rabbit mAb | Human,Mouse,Rat | WB |
R25739 | √ | √ | SMAC Rabbit mAb | Human,Mouse,Rat | WB,IHC-F,IHC-P,ICC/IF,IP |
381426 | √ |
| ATF4 Rabbit pAb | Human,Mouse,Rat | WB,IHC-P,ICC/IF,IP,FC |
应激,DNA损伤相关 | R23316 | √ | √ | DDIT3 Rabbit mAb | Human,Mouse | WB,IHC-P |
381868 |
|
| Calpain 1 Rabbit pAb | Human,Mouse,Rat | WB,IHC-P,ICC/IF,FC |
R24780 | √ | √ | JNK Rabbit mAb | Mouse,Rat | WB,ICC/IF,IP |
R26311 | √ | √ | Phospho-JNK1 (Thr183/Tyr185) Rabbit mAb | Human | WB,IP |
R25247 | √ | √ | p53 Rabbit mAb | Human | WB,ICC/IF |